122_enzymes_transporting_lipids_in_reviewed_human

rq turtle/ttl

• list
• reaction
• rhea

List all UniProtKB SwissProt entries, facilitation the transport of lipids.

Use at

• https://sparql.uniprot.org/sparql/

PREFIX up: <http://purl.uniprot.org/core/>
PREFIX rh: <http://rdf.rhea-db.org/>
PREFIX CHEBI: <http://purl.obolibrary.org/obo/CHEBI_>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX taxon: <http://purl.uniprot.org/taxonomy/>

SELECT
  ?protein
  ?chebi
WHERE {
  ?rhea rh:isTransport true .
  ?rhea rh:side/rh:contains/rh:compound ?compound .
  ?compound (rh:chebi|(rh:reactivePart/rh:chebi)|(rh:underlyingChebi/rh:chebi)) ?chebi .
  # CHEBI:18059 is the class for all Lipids
  ?chebi rdfs:subClassOf* CHEBI:18059 .
  
  # Select human reviewed entries from Swiss-Prot
  ?protein up:reviewed true ; 
    up:organism taxon:9606 .
   # Link protein to catalytic activity, then to Rhea reaction
  ?protein up:annotation?annotation .
  ?annotation up:catalyticActivity?catalytic_activity_obj .
  ?catalytic_activity up:catalyzedReaction?rhea .
}

graph TD
classDef projected fill:lightgreen;
classDef literal fill:orange;
classDef iri fill:yellow;
  v5("?annotation")
  v7("?catalytic_activity")
  v6("?catalytic_activity_obj")
  v3("?chebi"):::projected 
  v2("?compound")
  v4("?protein"):::projected 
  v1("?rhea")
  a1((" "))
  a2((" "))
  a3((" "))
  a4((" "))
  c13(["taxon:9606"]):::iri 
  c2(["true^^xsd:boolean"]):::literal 
  c10(["CHEBI:18059"]):::iri 
  v1 --"rh:isTransport"-->  c2
  v1 --"rh:side"-->  a1
  a1 --"rh:contains"-->  a2
  a2 --"rh:compound"-->  v2
  subgraph union0[" Union "]
  subgraph union0l[" "]
    style union0l fill:#abf,stroke-dasharray: 3 3;
    subgraph union1[" Union "]
    subgraph union1l[" "]
      style union1l fill:#abf,stroke-dasharray: 3 3;
      v2 --"rh:underlyingChebi"-->  a4
      a4 --"rh:chebi"-->  v3
    end
    subgraph union1r[" "]
      style union1r fill:#abf,stroke-dasharray: 3 3;
      v2 --"rh:reactivePart"-->  a3
      a3 --"rh:chebi"-->  v3
    end
    union1r <== or ==> union1l
    end
  end
  subgraph union0r[" "]
    style union0r fill:#abf,stroke-dasharray: 3 3;
    v2 --"rh:chebi"-->  v3
  end
  union0r <== or ==> union0l
  end
  v3 --"rdfs:subClassOf"-->  c10
  v4 --"up:reviewed"-->  c2
  v4 --"up:organism"-->  c13
  v4 --"up:annotation"-->  v5
  v5 --"up:catalyticActivity"-->  v6
  v7 --"up:catalyzedReaction"-->  v1