@prefix ex: <https://sparql.uniprot.org/.well-known/sparql-examples/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <https://schema.org/> .
@prefix sh: <http://www.w3.org/ns/shacl#> .

ex:189_pseudokinases a sh:SPARQLExecutable,
        sh:SPARQLSelectExecutable ;
    rdfs:comment "Find reviewed human pseudokinases: proteins with an annotated protein kinase domain but no annotated kinase (phosphotransferase) catalytic activity at all - a real, well-known biological category (catalytically-dead kinase domains repurposed for scaffolding/allosteric regulation, e.g. Tribbles homologs). The kinase domain itself is a up:Domain_Extent_Annotation whose rdfs:comment names it (\"Protein kinase\", sometimes qualified \"; inactive\" or \"; truncated\")"@en ;
    sh:prefixes _:sparql_examples_prefixes ;
    sh:select """PREFIX up: <http://purl.uniprot.org/core/>
PREFIX taxon: <http://purl.uniprot.org/taxonomy/>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>

SELECT
  ?protein
  ?domainComment
WHERE {
  ?protein up:reviewed true ;
    up:organism taxon:9606 ;
    up:annotation ?domain .
  ?domain a up:Domain_Extent_Annotation ;
    rdfs:comment ?domainComment .
  FILTER(CONTAINS(?domainComment, "Protein kinase"))
  FILTER(NOT EXISTS { ?protein up:enzyme|up:annotation/up:catalyticActivity/up:enzymeClass ?ec .
       ?ec rdfs:subClassOf <http://purl.uniprot.org/enzyme/2.7.-.->
  })
}""" ;
    schema:keywords "kinase" , "pseudoenzyme" , "domain" ;
    schema:target <https://sparql.uniprot.org/sparql/> .