@prefix ex: <https://sparql.uniprot.org/.well-known/sparql-examples/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <https://schema.org/> .
@prefix sh: <http://www.w3.org/ns/shacl#> .

ex:192_multifunctional_enzymes a sh:SPARQLExecutable,
        sh:SPARQLSelectExecutable ;
    rdfs:comment "Find reviewed multifunctional (multi-catalytic) enzymes: proteins annotated with more than one distinct EC number via up:enzyme or up:catalyticActivity - real biology (e.g. bifunctional enzymes in a biosynthetic pathway, or moonlighting enzymes), not just an EC-number-format curiosity."@en ;
    sh:prefixes _:sparql_examples_prefixes ;
    sh:select """PREFIX up: <http://purl.uniprot.org/core/>

SELECT
  ?protein
  (COUNT(DISTINCT ?ec) AS ?ecCount)
WHERE {
  ?protein up:reviewed true ;
    up:enzyme|up:annotation/up:catalyticActivity/up:enzymeClass ?ec .
}
GROUP BY ?protein
HAVING (COUNT(DISTINCT ?ec) > 1)""" ;
    schema:keywords "enzyme" , "EC number" , "multifunctional" ;
    schema:target <https://sparql.uniprot.org/sparql/> .