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217_proteins_in_a_cancer_pathway

rq turtle/ttl

• pathway
• Reactome
• cancer

Find reviewed human proteins that are part of a cancer-related Reactome pathway (matched by the pathway's own name), using the pathway cross-reference's rdfs:comment as the pathway's human-readable name

Use at

• https://sparql.uniprot.org/sparql/

PREFIX up: <http://purl.uniprot.org/core/>
PREFIX taxon: <http://purl.uniprot.org/taxonomy/>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>

SELECT
  ?protein
  ?pathway
  ?pathwayName
WHERE {
  ?protein a up:Protein ;
    up:organism taxon:9606 ;
    up:reviewed true ;
    rdfs:seeAlso ?pathway .
  ?pathway up:database <http://purl.uniprot.org/database/Reactome> ;
    rdfs:comment ?pathwayName .
  FILTER(CONTAINS(?pathwayName, "Cancer"))
}

graph TD
classDef projected fill:lightgreen;
classDef literal fill:orange;
classDef iri fill:yellow;
  v3("?pathway"):::projected 
  v1("?pathwayName"):::projected 
  v2("?protein"):::projected 
  c7(["true^^xsd:boolean"]):::literal 
  c10([http://purl.uniprot.org/database/Reactome]):::iri 
  c3(["up:Protein"]):::iri 
  c5(["taxon:9606"]):::iri 
  f0[["contains(?pathwayName,'Cancer')"]]
  f0 --> v1
  v2 --"a"-->  c3
  v2 --"up:organism"-->  c5
  v2 --"up:reviewed"-->  c7
  v2 --"rdfs:seeAlso"-->  v3
  v3 --"up:database"-->  c10
  v3 --"rdfs:comment"-->  v1