70_enzymes_interacting_with_molecules_similar_to_dopamine

Look for enzymes catalyzing reactions with molecules similar to dopamine.

Use at

• https://sparql.uniprot.org/sparql/

PREFIX CHEBI: <http://purl.obolibrary.org/obo/CHEBI_>
PREFIX rh: <http://rdf.rhea-db.org/>
PREFIX sachem: <http://bioinfo.uochb.cas.cz/rdf/v1.0/sachem#>
PREFIX up: <http://purl.uniprot.org/core/>

SELECT
  ?protein
  ?rhea
  ?chebi
WHERE {
  # Use the smiles of dopamine CHEBI:18243
  SERVICE <https://idsm.elixir-czech.cz/sparql/endpoint/chebi>{
    ?chebi sachem:similarCompoundSearch [
      sachem:query "NCCc1ccc(O)c(O)c1" ] .
  }
  GRAPH<https://sparql.rhea-db.org/rhea>{
    ?rhea rh:side/rh:contains/rh:compound ?compound .
    ?compound (rh:chebi|(rh:reactivePart/rh:chebi)|(rh:underlyingChebi/rh:chebi)) ?chebi .
  }
  ?protein up:reviewed true ;
    up:annotation ?caa .
  ?caa up:catalyticActivity/up:catalyzedReaction ?rhea .
}

graph TD
classDef projected fill:lightgreen;
classDef literal fill:orange;
classDef iri fill:yellow;
  v5("?caa")
  v1("?chebi"):::projected 
  v3("?compound")
  v4("?protein"):::projected 
  v2("?rhea"):::projected 
  a1((" "))
  a2((" "))
  a3((" "))
  a4((" "))
  a5((" "))
  a6((" "))
  c13(["true^^xsd:boolean"]):::literal 
  c3(["NCCc1ccc(O)c(O)c1"]):::literal 
  subgraph s1["https://idsm.elixir-czech.cz/sparql/endpoint/chebi"]
    style s1 stroke-width:4px;
    a1 --"sachem:query"-->  c3
    v1 --"sachem:similarCompoundSearch"-->  a1
  end
  v2 --"rh:side"-->  a2
  a2 --"rh:contains"-->  a3
  a3 --"rh:compound"-->  v3
  subgraph union0[" Union "]
  subgraph union0l[" "]
    style union0l fill:#abf,stroke-dasharray: 3 3;
    subgraph union1[" Union "]
    subgraph union1l[" "]
      style union1l fill:#abf,stroke-dasharray: 3 3;
      v3 --"rh:underlyingChebi"-->  a5
      a5 --"rh:chebi"-->  v1
    end
    subgraph union1r[" "]
      style union1r fill:#abf,stroke-dasharray: 3 3;
      v3 --"rh:reactivePart"-->  a4
      a4 --"rh:chebi"-->  v1
    end
    union1r <== or ==> union1l
    end
  end
  subgraph union0r[" "]
    style union0r fill:#abf,stroke-dasharray: 3 3;
    v3 --"rh:chebi"-->  v1
  end
  union0r <== or ==> union0l
  end
  v4 --"up:reviewed"-->  c13
  v4 --"up:annotation"-->  v5
  v5 --"up:catalyticActivity"-->  a6
  a6 --"up:catalyzedReaction"-->  v2