74_enzymes_with_at_least_two_transmembrane_domains

Find Hydrolases (enzymes that catalyse the hydrolysis of various bonds) that have at least two transmembrane domains

Use at

• https://sparql.uniprot.org/sparql/

PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX up: <http://purl.uniprot.org/core/>

SELECT
  ?protein
WHERE {
 ?protein up:enzyme|up:annotation/up:catalyticActivity/up:enzymeClass ?enzymeClass ;
                   up:annotation ?transMembraneAnnotation .
 ?enzymeClass rdfs:subClassOf <http://purl.uniprot.org/enzyme/3.-.-.-> .
 ?transMembraneAnnotation a up:Transmembrane_Annotation .
} GROUP BY ?protein HAVING (COUNT(DISTINCT ?transMembraneAnnotation) >= 2)

graph TD
classDef projected fill:lightgreen;
classDef literal fill:orange;
classDef iri fill:yellow;
  v4("?_anon_aaf95e3c346c4c97af230d5bcfeba8ab6469")
  v2("?enzymeClass")
  v1("?protein"):::projected 
  v3("?transMembraneAnnotation")
  a2((" "))
  a3((" "))
  a1((" "))
  c7([http://purl.uniprot.org/enzyme/3.-.-.-]):::iri 
  c9(["up:Transmembrane_Annotation"]):::iri 
  f0[[" >= '2^^xsd:integer'"]]
  f0 --> a1
  subgraph union0[" Union "]
  subgraph union0l[" "]
    style union0l fill:#abf,stroke-dasharray: 3 3;
    v1 --"up:annotation"-->  a2
    a2 --"up:catalyticActivity"-->  a3
    a3 --"up:enzymeClass"-->  v2
  end
  subgraph union0r[" "]
    style union0r fill:#abf,stroke-dasharray: 3 3;
    v1 --"up:enzyme"-->  v2
  end
  union0r <== or ==> union0l
  end
  v1 --"up:annotation"-->  v3
  v2 --"rdfs:subClassOf"-->  c7
  v3 --"a"-->  c9
  bind2[/"count(?transMembraneAnnotation)"/]
  v3 --o bind2
  bind2 --as--o v4