neXtProt/NXQ_00139

Protein kinases which are high-confidence drug targets according to CHEMBL

Use at

• https://sparql.nextprot.org/sparql

PREFIX : <http://nextprot.org/rdf/>
PREFIX cco: <http://rdf.ebi.ac.uk/terms/chembl#>
PREFIX nextprot_cv: <http://nextprot.org/rdf/terminology/>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX skos: <http://www.w3.org/2004/02/skos/core#>

SELECT DISTINCT ?entry (str(?gen) as ?gene) WHERE {
    SERVICE <https://idsm.elixir-czech.cz/sparql/endpoint/idsm> {
        SELECT DISTINCT ?protein WHERE {
            ?target cco:hasTargetComponent ?tarComp .
            ?target cco:taxonomy <http://identifiers.org/taxonomy/9606> . # human protein target
            ?tarComp cco:targetCmptXref ?protein .
            #?protein a cco:UniprotRef .
            FILTER(contains(str(?protein),"uniprot"))
            ?activity a cco:Activity ; cco:hasMolecule ?drug ; cco:hasAssay ?assay .
            ?drug cco:hasMechanism / cco:hasTarget ?target . # known drug action mechanism
            ?assay cco:hasTarget ?target; cco:targetConfScore ?score .
            FILTER(?score > 8) # high-confidence assay
        }
    }
    ?entry skos:exactMatch ?protein .
    ?entry :isoform / :uniprotKeyword / :term nextprot_cv:KW-0418. #kinase
    ?entry :gene / :recommendedName / rdfs:label ?gen.
}

graph TD
classDef projected fill:lightgreen;
classDef literal fill:orange;
classDef iri fill:yellow;
  v5("?activity")
  v7("?assay")
  v6("?drug")
  v8("?entry"):::projected 
  v9("?gen"):::projected 
  v10("?gene")
  v2("?protein")
  v1("?score")
  v4("?tarComp")
  v3("?target")
  a1((" "))
  a2((" "))
  a3((" "))
  a4((" "))
  a5((" "))
  c19([":terminology/KW-0418"]):::iri 
  c6([http://identifiers.org/taxonomy/9606]):::iri 
  c9(["cco:Activity"]):::iri 
  subgraph s1["https://idsm.elixir-czech.cz/sparql/endpoint/idsm"]
    style s1 stroke-width:4px;
    f0[["?score > '8^^xsd:integer'"]]
    f0 --> v1
    f1[["contains(str(?protein),'uniprot')"]]
    f1 --> v2
    v3 --"cco:hasTargetComponent"-->  v4
    v3 --"cco:taxonomy"-->  c6
    v4 --"cco:targetCmptXref"-->  v2
    v5 --"a"-->  c9
    v5 --"cco:hasMolecule"-->  v6
    v5 --"cco:hasAssay"-->  v7
    v6 --"cco:hasMechanism"-->  a1
    a1 --"cco:hasTarget"-->  v3
    v7 --"cco:hasTarget"-->  v3
    v7 --"cco:targetConfScore"-->  v1
  end
  v8 --"skos:exactMatch"-->  v2
  v8 --":isoform"-->  a2
  a2 --":uniprotKeyword"-->  a3
  a3 --":term"-->  c19
  v8 --":gene"-->  a4
  a4 --":recommendedName"-->  a5
  a5 --"rdfs:label"-->  v9
  bind2[/"str(?gen)"/]
  v9 --o bind2
  bind2 --as--o v10