neXtProt/NXQ_00252

Protein kinases involved in cancer pathways according to wikipathways

Use at

• https://sparql.nextprot.org/sparql

PREFIX : <http://nextprot.org/rdf/>
PREFIX cv: <http://nextprot.org/rdf/terminology/>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX dc: <http://purl.org/dc/elements/1.1/>

PREFIX wp: <http://vocabularies.wikipathways.org/wp#>
PREFIX dcterms: <http://purl.org/dc/terms/>

select distinct ?entry ?gen ?pathwayname where {
SERVICE <https://sparql.wikipathways.org/sparql> {
SELECT DISTINCT ?pathwayname ?gen WHERE
{
  {?geneProduct a wp:Protein}
    union
  {?geneProduct a wp:GeneProduct}

  ?geneProduct rdfs:label ?gen .
  ?geneProduct dcterms:isPartOf ?pathway .
  ?pathway a wp:Pathway .
  ?pathway wp:organism ?organism .
  FILTER(contains(str(?organism),"9606"))
  ?pathway dc:title ?pathwayname .
  FILTER(regex(?pathwayname,"cancer","i")). }
}
?entry a :Entry .
?entry :gene / :name / rdfs:label ?gen .
?entry :isoform / :enzymeClassification / :term /:childOf cv:2_7_-_- . # protein kinase activity
}
order by ?gen

graph TD
classDef projected fill:lightgreen;
classDef literal fill:orange;
classDef iri fill:yellow;
  v6("?entry"):::projected 
  v1("?gen"):::projected 
  v4("?geneProduct")
  v3("?organism")
  v5("?pathway")
  v2("?pathwayname"):::projected 
  a1((" "))
  a2((" "))
  a3((" "))
  a4((" "))
  a5((" "))
  c6(["wp:Protein"]):::iri 
  c20([":terminology/2_7_-_-"]):::iri 
  c10(["wp:Pathway"]):::iri 
  c7(["wp:GeneProduct"]):::iri 
  c13([":Entry"]):::iri 
  subgraph s1["https://sparql.wikipathways.org/sparql"]
    style s1 stroke-width:4px;
    f0[["regex(?pathwayname,'cancer','i')"]]
    f0 --> v2
    f1[["contains(str(?organism),'9606')"]]
    f1 --> v3
    subgraph union0[" Union "]
    subgraph union0l[" "]
      style union0l fill:#abf,stroke-dasharray: 3 3;
      v4 --"a"-->  c7
    end
    subgraph union0r[" "]
      style union0r fill:#abf,stroke-dasharray: 3 3;
      v4 --"a"-->  c6
    end
    union0r <== or ==> union0l
    end
    v4 --"rdfs:label"-->  v1
    v4 --"dcterms:isPartOf"-->  v5
    v5 --"a"-->  c10
    v5 --"wp:organism"-->  v3
    v5 --http://purl.org/dc/elements/1.1/title-->  v2
  end
  v6 --"a"-->  c13
  v6 --":gene"-->  a1
  a1 --":name"-->  a2
  a2 --"rdfs:label"-->  v1
  v6 --":isoform"-->  a3
  a3 --":enzymeClassification"-->  a4
  a4 --":term"-->  a5
  a5 --":childOf"-->  c20