neXtProt/NXQ_00300

Proteins with protein existence "At protein level" (PE=1) that have no function annotated, are highly expressed in brain and have homologs in Drosophila melanogaster according to OrthoDB

Use at

• https://sparql.nextprot.org/sparql

PREFIX : <http://nextprot.org/rdf/>
PREFIX nextprot_cv: <http://nextprot.org/rdf/terminology/>
PREFIX orthodb: <http://purl.orthodb.org/>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX up: <http://purl.uniprot.org/core/>

select ?entry (str(?name) as ?human_name) (group_concat(distinct str(?fly_name); SEPARATOR = ",") as ?fly_names) where
{
?entry :isoform ?iso.
?entry :gene / :recommendedName / rdfs:label ?name.
?entry :existence :Evidence_at_protein_level .
filter not exists { ?iso :functionInfo ?_. }
filter not exists { ?iso :catalyticActivity ?_ .}
filter not exists { ?iso :transportActivity ?_ .}
filter not exists { ?iso :pathway ?_. }
filter not exists { ?iso :function / :term ?fterm . filter(?fterm != nextprot_cv:GO_0005524 && ?fterm != nextprot_cv:GO_0000287 && ?fterm != nextprot_cv:GO_0005515 && ?fterm != nextprot_cv:GO_0042802 && ?fterm != nextprot_cv:GO_0008270 && ?fterm != nextprot_cv:GO_0051260 && ?fterm != nextprot_cv:GO_0005509 && ?fterm != nextprot_cv:GO_0003676 && ?fterm != nextprot_cv:GO_0003824 && ?fterm != nextprot_cv:GO_0007165 && ?fterm != nextprot_cv:GO_0035556 && ?fterm != nextprot_cv:GO_0046914 && ?fterm != nextprot_cv:GO_0046872)}
?iso :expression ?e1.
?e1 :term/:childOf nextprot_cv:TS-0095;:evidence/:observedExpression :High.
{
SERVICE <https://sparql.orthodb.org/sparql>
{?gene rdfs:seeAlso ?entry; orthodb:memberOf ?og.
?og orthodb:ogBuiltAt [up:scientificName ?clade]
; orthodb:hasMember ?ortholog.
?ortholog orthodb:name ?fly_name; up:organism/a/up:scientificName 'Drosophila melanogaster'.
filter (?clade='Metazoa') }
}
} group by ?entry ?name

graph TD
classDef projected fill:lightgreen;
classDef literal fill:orange;
classDef iri fill:yellow;
  v3("?_")
  v7("?clade")
  v6("?e1")
  v4("?entry"):::projected 
  v11("?fly_name"):::projected 
  v13("?fly_names")
  v1("?fterm")
  v8("?gene")
  v12("?human_name")
  v2("?iso")
  v5("?name"):::projected 
  v9("?og")
  v10("?ortholog")
  a2((" "))
  a3((" "))
  a1((" "))
  a4((" "))
  a5((" "))
  a6((" "))
  a7((" "))
  a8((" "))
  c25([":Evidence_at_protein_level"]):::iri 
  c28([":terminology/TS-0095"]):::iri 
  c31([":High"]):::iri 
  c42(["Drosophila melanogaster"]):::literal 
  f0[["not  "]]
  subgraph f0e0["Exists Clause"]
    e0f0[["?fterm != ':terminology/GO_0005524'?fterm != ':terminology/GO_0000287'?fterm != ':terminology/GO_0005515'?fterm != ':terminology/GO_0042802'?fterm != ':terminology/GO_0008270'?fterm != ':terminology/GO_0051260'?fterm != ':terminology/GO_0005509'?fterm != ':terminology/GO_0003676'?fterm != ':terminology/GO_0003824'?fterm != ':terminology/GO_0007165'?fterm != ':terminology/GO_0035556'?fterm != ':terminology/GO_0046914'?fterm != ':terminology/GO_0046872'"]]
    e0f0 --> e0v1
    e0v2 --":function"-->  e0a1
    e0a1 --":term"-->  e0v1
    e0v1("?fterm"):::projected 
    e0v2("?iso"):::projected 
    e0a1((" ")):::projected 
  end
  f0--EXISTS--> f0e0
  f0 --> v1
  f0 --> v2
  f0 --> c14
  f0 --> a1
  f0 --> c15
  f1[["?fterm != ':terminology/GO_0005524'?fterm != ':terminology/GO_0000287'?fterm != ':terminology/GO_0005515'?fterm != ':terminology/GO_0042802'?fterm != ':terminology/GO_0008270'?fterm != ':terminology/GO_0051260'?fterm != ':terminology/GO_0005509'?fterm != ':terminology/GO_0003676'?fterm != ':terminology/GO_0003824'?fterm != ':terminology/GO_0007165'?fterm != ':terminology/GO_0035556'?fterm != ':terminology/GO_0046914'?fterm != ':terminology/GO_0046872'"]]
  f1 --> v1
  v2 --":function"-->  a1
  a1 --":term"-->  v1
  f2[["not  "]]
  subgraph f2e1["Exists Clause"]
    e1v1 --":pathway"-->  e1v2
    e1v2("?_"):::projected 
    e1v1("?iso"):::projected 
  end
  f2--EXISTS--> f2e1
  f2 --> v2
  f2 --> c16
  f2 --> v3
  v2 --":pathway"-->  v3
  f3[["not  "]]
  subgraph f3e2["Exists Clause"]
    e2v1 --":transportActivity"-->  e2v2
    e2v2("?_"):::projected 
    e2v1("?iso"):::projected 
  end
  f3--EXISTS--> f3e2
  f3 --> v2
  f3 --> c17
  f3 --> v3
  v2 --":transportActivity"-->  v3
  f4[["not  "]]
  subgraph f4e3["Exists Clause"]
    e3v1 --":catalyticActivity"-->  e3v2
    e3v2("?_"):::projected 
    e3v1("?iso"):::projected 
  end
  f4--EXISTS--> f4e3
  f4 --> v2
  f4 --> c18
  f4 --> v3
  v2 --":catalyticActivity"-->  v3
  f5[["not  "]]
  subgraph f5e4["Exists Clause"]
    e4v1 --":functionInfo"-->  e4v2
    e4v2("?_"):::projected 
    e4v1("?iso"):::projected 
  end
  f5--EXISTS--> f5e4
  f5 --> v2
  f5 --> c19
  f5 --> v3
  v2 --":functionInfo"-->  v3
  v4 --":isoform"-->  v2
  v4 --":gene"-->  a2
  a2 --":recommendedName"-->  a3
  a3 --"rdfs:label"-->  v5
  v4 --":existence"-->  c25
  v2 --":expression"-->  v6
  v6 --":term"-->  a4
  a4 --":childOf"-->  c28
  v6 --":evidence"-->  a5
  a5 --":observedExpression"-->  c31
  subgraph s1["https://sparql.orthodb.org/sparql"]
    style s1 stroke-width:4px;
    f6[["?clade = 'Metazoa'"]]
    f6 --> v7
    v8 --"rdfs:seeAlso"-->  v4
    v8 --"orthodb:memberOf"-->  v9
    a6 --"up:scientificName"-->  v7
    v9 --"orthodb:ogBuiltAt"-->  a6
    v9 --"orthodb:hasMember"-->  v10
    v10 --"orthodb:name"-->  v11
    v10 --"up:organism"-->  a7
    a7 --"a"-->  a8
    a8 --"up:scientificName"-->  c42
  end
  bind8[/"str(?name)"/]
  v5 --o bind8
  bind8 --as--o v12
  bind9[/"str(?fly_name)"/]
  v11 --o bind9
  bind9 --as--o v13